Vascular Remodelling and Mesenchymal Transition in Systemic Sclerosis
Fibrosis of the skin and of internal organs, autoimmunity, and vascular inflammation are hallmarks of Systemic Sclerosis (SSc).The injury and activation of endothelial cells, with hyperplasia of the intima and eventual obliteration of the vascular lumen, are early features of SSc.Reduced capillary blood flow coupled with Jersey deficient angiogenes